The P0 Gene

摘要: Publisher Summary Protein zero (P0) is the major structural protein in myelin of peripheral nervous system (PNS). P0 has three domains: extracellular, transmembrane, and cytoplasmic. To date, only recombinant extracellular domain corresponding to sequence for rat been crystallized. This chapter focuses on what now known about P0, updating presented some earlier recent reviews. understand role membrane adhesion its mechanism action, a model should be developed which alterations can engineered introduced transgenically into an animal, ramifications across hierarchy development, nerve function, structure interactions determined. While use vitro systems provided clues considerable progress made using transgenic mice, it anticipated that exploitation zebrafish vertebrate myelination may also lead additional rapid progress.