Uterine and placental KISS1 regulate pregnancy: what we know and the challenges that lie ahead

摘要: Hypothalamic KISS1 and its derivatives (kisspeptins) are now well recognized as potent stimulators of GnRH secretion thereby major regulators the neuroendocrine-reproductive axis. Recent studies in mouse strongly suggest that independent hypothalamus pituitary, peripherally derived also regulates fertility, disruption local signaling ovary uterus is sufficient to trigger infertility. With this increasing recognition first goal review critically discuss data have led conclusion, focusing on uterine- placental-derived KISS1. Given a significant amount was generated animals such rat, second identify limitations animal context better understanding regulator human pregnancy. The growing evidence suggests both man mouse, plays an important role regulating very early pregnancy events embryo implantation. However, advances, although it seems continues play roles pregnancy, might not do so mouse. This surprising functional dichotomy between females mice appears exist women large number species, including lower primates. These findings tremendous significance will greatly shape how be developed therapeutic agent augmenting reproductive potential livestock species.