Family history and risk of stomach cancer in Italy

摘要: One thousand sixteen gastric cancer (GC) patients and 1623 population controls, interviewed in a multicentric study Italy, reported their family history for gastric, esophageal, colorectal cancer. A significant association was found only with of GC sibling or parent [odds ratio (OR), 2.6 1.7, respectively], which persisted after adjusting potential confounders including nutrient intake. Adjusted risk higher subjects having an affected mother than father (OR, 2.3 1.3) showed further increase reporting both parents 3.0) two more siblings 8.5). The proportion first-degree relative among females, the elderly, high-risk areas. Among adult controls cases, prevalence at interview 1 2.7%, respectively; shown families least one (1.4 5.7%). associated positive greater residents low-risk areas where risks were increased about two-fold. not related to blood group histological type according Lauren classification. These findings are discussed terms contributions genetic environmental factors possible interactions.