Hippocampal atrophy in temporal lobe epilepsy is correlated with limbic systems atrophy

摘要: Hippocampal sclerosis in temporal lobe epilepsy (TLE) is often associated with hippocampal atrophy. This study assessed whether such atrophy correlated loss of gray matter volume other brain regions. In 16 patients TLE and clear magnetic resonance imaging-based evidence sclerosis, volumes were determined manually the local (LGM) amount was estimated throughout entire using voxel-based morphometry. Voxelwise correlations between sclerotic hippocampus LGM computed. The pattern voxels whose outlined remarkably well anatomy extended limbic system included parahippocampal region, cingulate gyrus its extent, basal forebrain, thalamic nuclei, medial orbitofrontal areas insula. These emerged mainly on side ipsilateral to affected but also found contralaterally. No a group healthy controls. present data show that widespread systems findings are helpful better understand functional deficit reorganization will provide basis assess neural plasticity for those who undergo curative surgery.