High prevalence of phagocytic-resistant capsular serotypes of Klebsiella pneumoniae in liver abscess.

摘要: To better understand the role of capsular polysaccharide (CPS) K1 or K2 in Klebsiella pneumoniae liver abscess as well development metastasis to eye, neutrophil phagocytosis 70 CPS isolates including (n = 23)/K2 10), non-K1/K2 37) was evaluated by flow cytometry, fluorescence imaging, and electron microscopy. K1/K2 were significantly more resistant (P < 0.0001) than displayed increased resistance intracellular killing. Although mucoid phenotype (M-type) 0.0029) M-type non-K1/K2, no significant difference rate observed between with non-M-type 0.0924). Mucoidy is an associated factor that predominant isolates, but which itself not independent influence on phagocytic resistance. The proved non-abscess 0.0001), suggesting generally virulent both non-liver conditions. These findings indicate K. killing presumably contributes their high prevalence uniquely endophthalmitis.