Metabolic Abnormalities and Risk for Colorectal Cancer in the Physicians' Health Study

摘要: Background: Obesity and diabetes are established risk factors for colorectal cancer but have mainly been assessed independently. There few data about whether the metabolic syndrome, which refers to a clustering of cardiovascular disease thought be related insulin resistance, including obesity, type 2 diabetes, hyperlipidemia, hypertension, is associated with risk. Methods: During after randomized trial aspirin β-carotene, 22,071 healthy male physicians, initially ages 40 84 years, reported overweight (body mass index, ≥27 kg/m2), elevated blood pressure (≥130/85 mmHg or use antihypertensive medication), hypercholesterolemia (≥240 mg/dL lipid-lowering occurrence on annual questionnaires. Adjusted relative risks (RR) 95% confidence intervals (95% CI) time-varying abnormalities were estimated using multivariable proportional hazards model. Results: 369,966 person-years follow-up (median, 19 years), 494 physicians developed cancer. With aging cohort, prevalence having two more increased from 13% 35%. Overweight (RR, 1.4; CI, 1.1-1.7) 1.5; 1.1-2.0) cancer, whereas 1.1; 0.9-1.3) 0.9; 0.7-1.1) not. This model assessing independently was predictive than based number (each additional abnormality RR, 1.16; 1.05-1.29). Conclusions: Out markers syndrome assessed, whereas, in contrast their role disease, (Cancer Epidemiol Biomarkers Prev 2006;15(12):2391–7)