p53 protein overexpression and response to biomodulated 5-fluorouracil chemotherapy in patients with advanced colorectal cancer

摘要: Biomodulated 5-fluorouracil (5-FU) chemotherapy may limit disease progression in up to 50% of patients with metastatic or unresectable carcinoma the colorectum. However, treatment is expensive and be toxic. Thus any predictors response clinically economically valuable. The p53 gene mutated more than colorectal tumours, usually resulting overexpression. It regulate cell cycle cellular DNA damage. principal anticancer activity 5-FU due its ability induce Fifty-nine received bolus intravenous 5-FU/folinic acid over 3 months. Response was assessed by CAT scan (WHO criteria). protein overexpression determined immunohistochemically from paraffin sections original primary tumour resected metastases. Tumour expression associated a lower rate reponse higher deterioration both radiologically ( P 2 test for trend), but did not predict survival start treatment. unrelated age, sex, grade, site schedule. alone cannot used select advanced cancer useful association other markers biology.