Correlated effects of selection for immunity in White Leghorn chicken lines on natural antibodies and specific antibody responses to KLH and M. butyricum.

摘要: The effect of selection for three general immune response traits on primary antibody responses (Ab) to Mycobacterium butyricum or keyhole limpet hemocyanin (KLH) was studied in four experimental lines White Leghorn chicken. Birds underwent 12 generations one different criteria; high Newcastle disease virus 3 weeks after vaccination (ND3), cell-mediated response, using the wing web phytohemglutinin (PHA) and phagocytic activity, measured as carbone clearance (CC). Line ND3-L selected ND3, line PHA-L PHA, CC-L CC, but all were traits. fourth a contemporary random bred control maintained throughout experiment. Principal component analysis used distinguish clusters based overall set measures. In KLH immunised group, no differences present between natural antibodies binding LPS, and, had higher titers LTA anti-Gal before immunisation protocol. measure ND3 correlated positively with LPS post difference at day 0 7 immunisation. M. showed significantly specific butyricum, this result agrees well hypothesis that Th-1 pathway expected be line. This study has shown two antigens gave rise lines, only enhanced antigen associated same mechanism trait (ND3, PHA CC) which selected. Interactions innate acquired immunity have been observed mainly trait, indicating there interaction due criterion. Furthermore, results confirmed independence Finally, principal contributed visually discriminate low responders new lines.