Bitter gourd (Momordica charantia) as a rich source of bioactive components to combat cancer naturally: Are we on the right track to fully unlock its potential as inhibitor of deregulated signaling pathways.

摘要: Research over decades has progressively explored pharmacological actions of bitter gourd (Momordica charantia). Biologically and pharmacologically active molecules isolated from M. charantia have shown significant anti-cancer activity in cancer cell lines xenografted mice. In this review spotlight was set on the bioactive compounds that effectively inhibited development progression via regulation protein network cells. We summarize most recent high-quality research work mice related to tumor suppressive role-play its compounds. Although mediated health promoting, anti-diabetic, hepatoprotective, anti-inflammatory effects been extensively investigated, there is insufficient information signaling networks by obtained different cancers. modulate AKT/mTOR/p70S6K signaling, p38MAPK-MAPKAPK-2/HSP-27 pathway, cycle regulatory proteins apoptosis-associated However, still are visible knowledge gaps drug targets cancers because we not yet developed comprehensive understanding signal transduction pathways. To explore these questions, experimental platforms needed can prove be helpful getting a step closer personalized medicine.