Fibroblast growth factor 2 control of vascular tone.

摘要: Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved many developmental homeostatic processes, including of the tissue layers walls, functions vascular control. Fgf2 knockout mice are morphologically normal display decreased smooth muscle contractility, low thrombocytosis. Following intra-arterial mechanical injury, FGF2-deficient vessels undergo hyperplastic response. These results force us reconsider function FGF2 development homeostasis terms