Improved Survival in Down Syndrome over the Last 60 Years and the Impact of Perinatal Factors in Recent Decades.

摘要: Objective To calculate the survival of people with Down syndrome over past 60 years and influence major perinatal factors by using linked population-based data. Study design A data linkage between 2 Western Australian (WA) sets (the Register for Developmental Anomalies Intellectual Disability Exploring Answers database) was used to identify 772 children born in WA from 1980-2010. Perinatal mortality were extracted Midwives Information System death registrations compared remaining population during that same era. An additional 606 living prior 1980 available a disability services database predicting into adulthood. Results Overall, cases 1953-2010, 88% (95% CI 86%, 90%) survived 5 years age, 87% 85%, 89%) 10 years, 83% 80%, 85%) 30 years. Children live-born significantly more likely (all P  > .001) have mothers older than 35 years (32.7% vs 13.4%), gestational age less 37 weeks (23.8% 7.9%), cesarean delivery (28.9% 23.0%), birth weight 2500 g (20.4% 6.1%). reduced presence cardiovascular defect, younger low weight, or earlier years. Conclusions Improved last has occurred incrementally, but disparities still exist who are preterm weight.