Further characterization of responses of infants and children to meningococcal A polysaccharide vaccine

摘要: The responses to 10 or 50 microgram doses of meningococcal group A polysaccharide vaccine were evaluated in infants and children. Although the dose was shown be more effective induction detectable anti-A antibody vaccinees all ages, only 6.5% (7/108) smaller than equal 12 months demonstrated a "protective level" (greater 2 mug/ml protein) at 28 35 days postinoculation. Unexpected variations response different lots, supplied by three manufactures, observed. These findings indicate need for additional studies before routine immunization young can recommended.