Prevalence and cost of nonadherence to antiepileptic drugs in elderly patients with epilepsy
作者： Alan B. Ettinger , Ranjani Manjunath , Sean D. Candrilli , Keith L. Davis
DOI: 10.1016/J.YEBEH.2008.10.021
关键词:
摘要: Retrospective insurance claims from the United States were analyzed to assess nonadherence antiepileptic drugs (AEDs) and association between AED nonadherence, seizures, health care costs in elderly persons with epilepsy. Inclusion criteria were: age 65, epilepsy diagnosis 1 January 2000 31 June 2006, 2 prescriptions, enrollment for 6 months pre- 12 post-AED initiation. Adherence was evaluated using medication possession ratio (MPR), MPR<0.8 defining nonadherence. Per-patient outcomes over Of 1278 patients identified, 41% nonadherent. Seizure, defined by epilepsy-related inpatient or emergency department admission, occurred 12.1% of nonadherers versus 8.2% adherers (P=0.0212). Nonadherers had higher (+$872, P=0.001), (+$143, P=0.0008), other outpatient ancillary (+$1741, P=0.0081), total (+$2674, P=0.0059) costs. adherence among is suboptimal associated increased seizures
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