Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells

摘要: Psycho-social stress has been suggested to influence the development of cancer, but it remains poorly defined with regard pancreatic a lethal malignancy few effective treatment modalities. In this study, we sought investigate impacts enriched environment (EE) housing, rodent model "eustress'', on growth mouse and explore potential underlying mechanisms through gene expression profiling. The EE mice showed significantly reduced tumor weights in both subcutaneous (53%) orthotopic (41%) models, while each single component (inanimate stimulation, social stimulation or physical exercise) was not profound enough achieve comparative anti-tumor effects as EE. integrative transcriptomic proteomic analysis revealed that response EE, total 129 genes tumors differential at mRNA protein levels. differentially expressed were mostly localized mitochondria citrate cycle oxidative phosphorylation pathways. Interestingly, nearly all mitochondria-related down-regulated by Our data have provided experimental evidence favor application positive benign environmental cancer therapy.