PrPSc causes nerve cell death and stimulates astrocyte proliferation: a paradox.

摘要: Publisher Summary The chapter describes the differential effects of central nervous system (CNS) disorders on neurons and astrocytes as a paradox to emphasize that molecular mechanisms underlying different responses are not completely understood. It is reviewed evidence from studies prion diseases suggests single abnormal nerve cell protein, PrP SC , causes both neuronal degeneration astrocytic proliferation. New testable hypotheses have emerged Ca 2+ regulation in scrapie-infected lines, which propose exerts its cells by altering ion channel function, specifically mechanisms. data also suggest whether injured or flourishes dependent specific repertoire regulatory Whether itself stimulates Ca2+ channels influence mitotic activity glia, it dysfunction leads their currently being investigated.