CNS amyloid proteins in neurodegenerative diseases.

摘要: The amyloid plaques found in neurodegenerative diseases show considerable morphologic diversity. Two amyloidogenic proteins have been isolated from the brains of humans and animals with diseases--beta-protein Alzheimer's disease (AD) Down's syndrome, prion protein (PrP) scrapie Creutzfeldt-Jakob (CJD). Using monoclonal antibodies to a synthetic peptide corresponding portion beta-protein rabbit antiserum hamster PrP 27-30, we examined situ on sections cases diseases, including spectrum plaque types. Anti-beta-peptide stained cerebrovascular core all AD as well senile five elderly CJD cases. Anti-PrP CJD, kuru, Gerstmann-Straussler syndrome but not or AD. Dual localization experiments showed that mixture types, identified different populations anatomic heterogeneity. Colocalization two was observed any type. data suggest major types exist, which etiologic origins. Our results emphasize need for classification CNS amyloids based their morphology macromolecular components comprising these pathologic polymers.