GFAP and Astrogliosis
作者： Lawrence F. Eng , Roopa S. Ghirnikar
DOI: 10.1111/J.1750-3639.1994.TB00838.X
关键词: Central nervous system 、 Disease 、 Neuroscience 、 AIDS dementia 、 Traumatic brain injury 、 Biology 、 Pathology 、 Astrogliosis 、 Glial fibrillary acidic protein
摘要: One of the most remarkable characteristics astrocytes is their vigorous response to diverse neurologic insults, a feature that well conserved across variety different species. The astroglial occurs rapidly and can be detected within one hour focal mechanical trauma (Mucke et al., 1991). Prominent reactive astrogliosis seen; in AIDS dementia; other viral infections; prion associated spongiform encephalopathies; inflammatory demyelinating diseases; acute traumatic brain injury; neurodegenerative diseases such as Alzheimer's disease. prominence reactions various diseases, rapidity evolutionary conservation indicate fulfill important functions central nervous system (CNS). Yet, exact role play injured CNS has so far remained elusive. This chapter summaries experimental models exhibit increase glial fibrillary acidic protein (GFAP). Recent vitro studies inhibit GFAP synthesis are also presented.
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