Mucosal bacteria in ulcerative colitis

摘要: Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease of unknown aetiology, although bacterial species belonging to the normal colonic microbiota are known be involved in its initiation maintenance. Several organisms have been linked disease; however, mucosa-associated bacteria more likely than their luminal counterparts, due close proximity host epithelium. Comparative bacteriological analyses were done on rectal biopsies investigate differences mucosal patients with UC healthy controls. Complex communities found both groups, significant reductions bifidobacterial numbers UC, which suggested that they might a protective role disease. Accordingly, therapy for treating was designed, aim modifying increase colonisation reduce inflammation. Ranges faecal bifidobacteria tested substrate preferences abilities survive under variety environmental conditions. A synbiotic comprising probiotic (Bifidobacterium longum) isolated from mucosa combined prebiotic (oligofructose-enriched inulin - Synergy 1) developed. The treatment used randomised controlled trial involving eighteen active period 1 month. Rectal collected at beginning end study. Bacteriological analysis transcription levels epithelium-related immune markers assessed. Results demonstrated short-term resulted increased induced expression molecules control inflammation UC.