Combined use of chiral ionic liquid surfactants and neutral cyclodextrins: evaluation of ionic liquid head groups for enantioseparation of neutral compounds in capillary electrophoresis.

摘要: Cyclodextrins (CDs) are most commonly used chiral selectors in capillary electrophoresis (CE). Although the use of neutral CDs and its derivatives have shown to resolve plethora charged enantiomers, they cannot enantiomers. The ionic liquids (ILs) surfactants forming successful complex with present itself an opportunity In this work, effect IL head groups their complexation ability heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD) was studied for separation enantiomers by CE. First, cationic type different were synthesized. Physicochemical properties such as critical micelle concentration determined surface tension, whereas aggregation polarity fluorescence spectroscopy. ILs TM-β-CD characterized gas phase CE-mass spectrometry. influence group on resolution, resolution per unit time selectivity investigated four structurally diverse compounds. binding constants analytes IL-CD estimated y-reciprocal method. hydrophobicity side chain displayed significant enantioseparations.