Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay.
作者： Petra Knizetova , Jiri Ehrmann , Alice Hlobilkova , Iveta Vancova , Ondrej Kalita
DOI: 10.4161/CC.7.16.6442
关键词:
摘要: Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis and progression of malignant brain tumors. Given the significance tumor microenvironment general, established paracrine VEGF signaling glioblastoma (GBM) biology particular, we explored potential autocrine control human astrocytoma behavior by VEGF. Using range cell molecular approaches to study panel (grade III IV/GBM)-derived lines series clinical specimens from low- high-grade astrocytomas, show that co-expression receptors (VEGFRs) occurs commonly cells. We found secretion VEGF-induced biological effects (modulation cycle enhanced viability cells) function an manner. Morevover, demonstrated is mediated via VEGFR2 (KDR), involves co-activation c-Raf/MAPK, PI3K/Akt PLC/PKC pathways. Bloc...
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