Coordination-Driven Self-Assembly of Ionic Irregular Hexagonal Metallamacrocycles via an Organometallic Clip and Their Cytotoxicity Potency.
作者： Sourav Bhowmick , Achintya Jana , Khushwant Singh , Prerak Gupta , Ankit Gangrade
DOI: 10.1021/ACS.INORGCHEM.7B01561
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摘要: Two new irregular hexagons (6 and 7) were synthesized from a pyrazine motif containing an organometallic acceptor clip [bearing platinum(II) centers] different neutral donor ligands (4,4′-bipyridine or pyrazine) using coordination-driven self-assembly protocol. The two-dimensional supramolecules characterized by multinuclear NMR, mass spectrometry, elemental analyses. Additionally, one of the macrocycles (6) was single-crystal X-ray Macrocycles are unique examples [2 + 2] self-assembled ensembles that hexagonal but in shape. These hexagon frameworks require assembly only four tectons/subunits. cytotoxicity platinum(II)-based studied various cell lines such as A549 (human lung carcinoma), KB oral cancer), MCF7 breast HaCaT skin keratinocyte) lines, results compared with those cisplatin. smaller macrocycle (7) exhibited higher cytotoxic effect against al...
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