Methylation of the rat seminal vesicle secretory protein IV gene. Extensive demethylation occurs in several male sex accessory glands.

摘要: Abstract Seminal vesicle secretory protein IV (SVS IV) is perhaps the most abundant made by epithelial cells of rat seminal vesicle. In this report, we have asked whether methylation its gene correlates with tissue-specific pattern expression. Using methylation-sensitive restriction endonucleases HpaII and AvaI, could examine seven potential sites in or near gene. All were largely unmethylated vesicle, while nonexpressing organs, all heavily modified. The correlation demethylation expression was broken finding that both ventral prostate coagulating gland (anterior prostate) DNA showed same seen for SVS has not been reported either these two detect mature message RNA transcription vitro incubation nuclei. We conclude accompanies differentiation several androgen-dependent sex accessory glands but confirm per se a sufficient signal to bring about transcription.