Decrease in mercury concentration in blood after long term exposure: a kinetic study of chloralkali workers.
作者： G Sallsten , L Barregard , A Schutz
DOI: 10.1136/OEM.50.9.814
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摘要: The elimination of mercury (Hg) in blood was investigated 14 chloralkali workers exposed to metallic Hg vapour for 1-24 (median 10) years. Blood and urine samples were collected on several eight) occasions during a period 17-26 days. initial concentrations about 80 nmol/l whole (B-Hg) 17 nmol/mmol creatinine (U-Hg). decrease blood, plasma (P) erythrocytes (Ery) best characterised by two compartment model. In model with common half life all subjects, the fit B-Hg obtained lives 3.8 days fast phase 45 slow phase. shorter P-Hg than Ery-Hg, whereas opposite case phases longer, relative fractions higher (about 50%) after long term exposure those 20%) reported brief exposure. Slower indicates accumulation organs lives, possibly presence at least one additional, even slower compartment. U-Hg fluctuated substantially sampling period, average decreased only slightly.
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