The absorption, blood levels, and excretion of mercury after a single dose of mercury vapor in humans.

摘要: Nine healthy volunteers without amalgam fillings were exposed to 400 micrograms/m3 mercury vapor (Hg0) for 15 min, corresponding 5.5 nmol Hg0/kg body wt (median range: 4.4-7.2). Frequent sampling of blood, urine, and exhaled air was performed 30 days after exposure. The median retention Hg0 69% the inhaled dose. During first 3 exposure 7.5-12% absorbed dose lost by exhalation, with half time in expired breath being 2.0 days. In blood plasma, a rapid absorption phase Hg seen, followed biexponential decline curves both media. A substantial interindividual variation observed area under concentration-time plasma. plasma second 10 About 1.0% excreted via urine during exposure, whereas estimated amount ranged from 8 40%. order evaluate chronic dental general population, daily based on levels found subjects clearance obtained present study. 5-9 micrograms/day an ordinary number fillings.