By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?

摘要: Objective : To estimate by how much and quickly a given reduction in serum cholesterol concentration will reduce the risk of ischaemic heart disease. Design Data on incidence disease were analysed from 10 prospective (cohort) studies, three international studies different communities, 28 randomised controlled trials (with mortality data according to allocated treatment ensure avoidance bias). Main outcome measure - Decrease or for 0.6 mmol/l (about 10%) decrease concentration. Results For men results cohort showed that was associated with 54% at age 40 years, 39% 50, 27% 60, 20% 70, 19% 80. The combined (for ages 55-64 years) 38% (95% confidence interval 33% 42%), somewhat greater than study 27%. reductions 7% (0 14%) first two 22% (15% 28%) 2.1-5 25% 35%) after five last being lose long term studies. women are limited but indicate similar effect. Conclusions comparisons, clinical remarkably consistent. based half million 18 000 events, (10%), which can be achieved moderate dietary change,lowers 50% 40, falling 70. trials, 45 4000 events show full effect is years.