Reversible Toxic Effects of the Dietary Supplement Indole-3-Carbinol in an Immune Compromised Rodent Model: Intestine as the Main Target.

摘要: ABSTRACTDietary supplements are widely used in the United States, but safety issue remains unresolved. Immuno-deficient or immuno-compromised patients, estimated to exceed 10 million known use dietary supplements. This population potentially may be susceptible supplements’ adverse effects. The cruciferous vegetable-derived indole-3-carbinol (I3C) is for its possible protective effects against a number of chronic diseases and commercially available as supplement. However, orally consumed I3C general particularly individuals unknown. In this study, rodent model immune-deficient male BALB/c nu/nu athymic mice were given diets supplemented with 0-100 μmoles I3C/g diet 4 weeks. We found that not viable after three days on 100 μmoles diet. Switching control (without I3C) first detection stress resulted 75% recovery o...