Neural activity in the human brain relating to uncertainty and arousal during anticipation

摘要: Summary has led to a hypothesis that cerebral representation of anticipatory arousal biases behavior and guides strate- We used functional magnetic resonance neuroimag- gic decision-making (Damasio et al., 1991; Damasio,ing measure brain activity during delay between 1994; Bechara 1996). This behavioral bias may be reward-related decisions their outcomes, the dissociated from explicit, conscious knowledge about modulation this by uncertainty risk. Healthy subjects show preference for low-risk arousal. Feedback, indicating financial gain or loss, increased amplitude was given following fixed delay. Anticipatory skin-conductanceresponsestohigh-riskoptionsbefore indexed galvanic skin conductance. Delay- developing explicit awareness most advanta- period associated with bilateral activation geous strategy (Bechara 1997). More- in orbital medial prefrontal, temporal, right