Moringa oleifera Hydroethanolic Extracts Effectively Alleviate Acetaminophen-Induced Hepatotoxicity in Experimental Rats through Their Antioxidant Nature

摘要: The aim of the study was to investigate in vitro antioxidant properties Moringa oleifera Lam. (MO) extracts and its curative role acetaminophen (APAP)- induced toxic liver injury rats caused by oxidative damage. total phenolic content hydroethanolic different MO edible parts were investigated employing an established biological assay. In antihepatotoxic study, either flowers or leaves extract (200 mg/kg 400 mg/kg, i.p) administered hour after APAP administration, respectively. N-Acetylcysteine used as positive control against APAP-induced hepatotoxicity. levels markers such alanine aminotransferase (ALT) damage including malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) protein adduct, reduced glutathione (GSH), superoxide dismutase (SOD) catalase (CAT) analysed compared between experimental groups. Among flower contain highest capacity, followed extract. marker MDA, well 4-HNE adduct elevated GSH, SOD CAT significantly decreased groups treated with hepatotoxin. biochemical tissue measured showed a significant (p < 0.05) reduction severity results this strongly indicate therapeutic