Fully dilutable microemulsions embedded with phospholipids and stabilized by short-chain organic acids and polyols.
作者： Aviram Spernath , Abraham Aserin , Nissim Garti
DOI: 10.1016/J.JCIS.2006.02.024
关键词:
摘要: Evidence on the role of phosphatidylcholine (PC) as a membrane permeability enhancer was driving force in forming new liquid nanosized (modified microemulsions) oral delivery system containing PC molecules. In this study we have demonstrated feasibility constructing phase diagrams with large isotropic regions capable being fully diluted water. The microemulsions were stabilized mixtures composed and nonionic surfactant (polyoxyethylene-40 hydrogenated castor oil, HECO40) short-chain organic acid cosurfactant/cosolvent. When propionic served cosurfactant/cosolvent, region at its maximum (ca. 72% total diagram area). presence blend HECO40 seems to synergistic effects, an comprising area diagram, comparison 20 50% systems by HECO40, alone, respectively. molecules formation those is comparing three soy lecithins. Lecithin high content forms larger more "free dilution" lines. Several surfactants been investigated, yet only packing parameter suitable for U-type systems.
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