Multiple myeloma: the cells of origin--a two-way street.

摘要: Multiple myeloma results from an interplay between the monoclonal malignant plasma cells and supporting nonmalignant in bone marrow. Recent studies suggest that final transforming event this B cell disorder occurs at a late stage of differentiation based on characteristics immunoglobulin genes expressed by clone as well surface markers present tumor cells. Recently, increasing pathogenic role malignancy marrow has been suggested several studies. Specific infection these recently identified Kaposi's sarcoma-associated herpes virus (KSHV) suggests novel mechanism which population may lead to development support its growth.