Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers.
作者： Tarek A Ahmed , Alaa O Bawazir , Waleed S Alharbi , Martin K Safo
DOI: 10.2147/IJN.S256925
关键词:
摘要: Background Simvastatin (SMV), a hypocholesterolemic agent, suffers from very low bioavailability due to its poor aqueous solubility and extensive first-pass metabolism. Methods Two SMV carrier systems, namely, polymeric drug inclusion complex (IC) mixed micelles (MM) nanoparticles, were developed loaded into mucoadhesive buccal films enhance bioavailability. The two systems characterized their permeation across human oral epithelial cells (OEC) was studied. effect of IC MM ratio (X1) the polymer concentration (X2) on cumulative percent released, elongation strength, prepared films, optimized. Ex vivo bovine mucosal tissue investigated. parameters for in vitro ex release data calculated. Results Complexation with hydroxypropyl beta-cyclodextrin (HP β-CD) superior all other polymers as revealed by equilibrium saturation solubility, stability constant, complexation efficiency thermodynamic potential. SMV-HP β-CD utilized develop saturated solution. Both showed enhanced OEC when compared pure drug. X1 X2 significantly affecting characteristics films. optimized film formulation nanoparticles demonstrated corresponding film, calculated confirmed this finding. Conclusion Mucoadhesive containing can be used improve bioavailability; however, additional pharmacokinetic pharmacodynamic studies are required.
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