Neonatal deprivation of maternal touch may suppress ornithine decarboxylase via downregulation of the proto-oncogenes c-myc and max

摘要: Previously, we have shown that short-term (1 hr) separation of neonatal rats from their mother (MS) suppresses basal ornithine decarboxylase (ODC) synthesis and tissue ODC response to trophic factors. This effect in the pup is caused by absence maternal tactile stimulation (touch) but not lack nutrients (food). study was performed examine 10-d-old whether touch deprivation affects expression certain hepatic proto-oncogenes, protein products which are known interact with regulatory region gene. Prolactin (PRL) injected subcutaneously increased activity as well mRNA levels proto-oncogenes c-fos, c-jun, junB, junD, c-myc, max. MS significantly suppressed PRL-induced increases enzyme max, mRNAs had little on other proto-oncogenes. ODC, max also depressed neonates placed an anesthetized lactating dam (touch-deprived) pups nipple-ligated dams (food-deprived). Furthermore, unlike its preweanling-age (< 20 d old), did alter either or c-myc 25-d-old acutely separated mother. These findings indicate suppression gene transcription during may be mediated downregulation transactivator They consistent our previous observation touch, milk, initiates physiological alterations induced MS.