Vasoactive intestinal peptide: behavioral effects in the rat and hamster.

作者: P.J. Kulkosky , J.S. Doyle , V.I. Cook , G.W. Glazner , M.A. Foderaro

DOI: 10.1016/0091-3057(89)90331-6

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摘要: Abstract The behavioral effects of intracerebroventricular (ICV) injection the brain-gut peptide vasoactive intestinal (VIP) were quantified with a sampling technique in home-caged, nondeprived, male and female albino rats golden hamsters. ICV VIP sex-dependently decreased observed resting behavior during 1 hr after injections both hamsters at 0.1–10.0 μg. Grooming was increased hamsters, rearing standing behaviors rats, doses that resting. Drinking suppressed by 10.0 Intraperitoneal (IP) (100.0 μg/kg) 5% ethanol intake eating fluid-deprived rats. increase produced IP prevented cholecystokinin octapeptide (CCK, 4.0 μg/kg). potently controls ingestive behaviors, suggesting role for this neuropeptide, along CCK, feedback regulation rodent behavior.

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