Possible differentiation of cerebral glioblastoma into pleomorphic xanthoastrocytoma: an unusual case in an infant.

摘要: The authors describe an infant girl who, at 10 months of age, presented with a large right parietooccipital tumor causing increased intracranial pressure, mass effect, and midline shift. was completely resected, the entirety histology consistent glioblastoma. She subsequently placed on adjuvant high-dose chemotherapy consisting carboplatin, vincristine, temozolomide, according to Head Start III, Regimen C. Three after complete resection, recurrence noted MR imaging, during third cycle chemotherapy, biopsy revealed malignant astrocytoma. Given patient's intolerance palliative course pursued. Unexpectedly, patient alive had made significant developmental improvements 18 into palliation. Subsequently, however, signs pressure developed imaging demonstrated very new growth site prior resection. again fully but microscopy surprisingly pleomorphic xanthoastrocytoma throughout. clinicopathological genetic features this girl's unusual neoplasm are detailed potential pathogenic hypotheses explored in report.