Surface characteristics and in vitro biocompatibility of a manganese-containing titanium oxide surface
作者： Jin-Woo Park , Youn-Jeong Kim , Je-Hee Jang
DOI: 10.1016/J.APSUSC.2011.09.053
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摘要: Abstract This study investigated the surface characteristics and in vitro biocompatibility of a titanium (Ti) oxide layer incorporating manganese ions (Mn) obtained by hydrothermal treatment with expectation utilizing potent integrin–ligand binding enhancement effect Mn for future applications as an endosseous implant surface. The were evaluated scanning electron microscopy, thin-film X-ray diffractometry, photoelectron spectroscopy, optical profilometry inductively coupled plasma-atomic emission spectroscopy (ICP-AES). Mn-containing Ti was comparison untreated bare using mouse calvaria-derived osteoblastic cell line (MC3T3-E1). produced nanostructured Mn-incorporated approximately 0.6 μm thick. ICP-AES analysis demonstrated that released from hydrothermally treated into solution. incorporation notably decreased cellular attachment, spreading, proliferation, alkaline phosphatase activity, osteoblast phenotype gene expression compared ( p 0.05). results indicate Mn-incorporation has no evident beneficial effects on function, but instead, actually impaired behavior.
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