A prospective material for orthopedic applications: Ti substrates coated with a composite coating of a titania-nanotubes layer and a silver-manganese-doped hydroxyapatite layer

摘要: Abstract Orthopedic implants need to be coated with biomedical coatings that can facilitate osseointegration and mitigate bacterial biofilm formation. Using anodisation electrodeposition techniques, we modified Ti a double-layer coating made of TiO 2 nanotubes (TNT) hydroxyapatite was codoped silver manganese (AgMnHA). The incorporation into improves its antimicrobial properties, the doping offsets potential cytotoxicity incorporated silver. AgMnHA TNT films were characterized X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, energy-dispersive photoelectron spectroscopy. results highlight ions evenly AgMnHA/TiO coating. Its adhesion strength significantly increased because interlocking rough layer bioceramic particles entered voids nanotubes. decreases corrosion current density titanium from 3.71 μA 0.19 μA, increases resistance by almost two orders magnitude. continuously release suspension, resulting in excellent efficacy 100% reduction viable cells. Both are super-hydrophilic; meanwhile, if immersed simulated body fluid, they could induce deposition typical spherical apatite. In-vitro cell culture tests demonstrated considerably improved viability alkaline phosphatase (ALP) activity. Therefore, has no significant on osteoblasts, generate sufficient osteoblast differentiation for osseointegration. We therefore find bilayer antibiofilm properties does not offset biocompatibility is needed successful bone healing.