Integrin-mediated osteoblastic adhesion on a porous manganese-incorporated TiO2 coating prepared by plasma electrolytic oxidation
作者： ZHENXIANG ZHANG , BEIBEI GU , WEI ZHU , LIXIAN ZHU
关键词:
摘要: This study was conducted to evaluate the bioactivity of manganese-incorporated TiO2 (Mn-TiO2) coating prepared on titanium (Ti) plate by plasma electrolytic oxidation (PEO) technique in Ca-, P- and Mn-containing electrolytes. The surface topography, phase element compositions coatings were investigated using scanning electron microscopy (SEM), X-ray diffraction (XRD) energy dispersive spectrometry (EDS), respectively. adhesion osteoblast-like MG63 cells onto Ti, Mn-TiO2 surfaces evaluated, signal transduction pathway involved confirmed sequential expression genes for integrins β1, β3, α1 α3, focal kinase (FAK), extracellular regulated kinases (ERKs), including ERK1 ERK2. results obtained indicated that Mn successfully incorporated into porous nanostructured coating, did not alter topography or composition coating. Mn-incorporated significantly enhanced compared with Mn-free pure Ti plates. In addition, cell may have been mediated binding integrin subunits, β1 α1, subsequent pathway, involving FAK novel has potential orthopedic implant applications, further investigations are required.
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