FLAP: a novel drug target for inhibiting the synthesis of leukotrienes
作者： Anthony W. Ford-Hutchinson
DOI: 10.1016/0165-6147(91)90500-R
关键词:
摘要: FLAP (5-lipoxygenase-activating protein) is a novel 18 kDa membrane protein that together with 5-lipoxygenase required for cellular leukotriene biosynthesis. Tony Ford-Hutchinson describes class of biosynthesis inhibitor, exemplified by MK0886, can bind to high affinity, prevent the activation preventing translocation enzyme from cytosol and inhibit production. The term 'translocation inhibitors' may be used inhibitors such as MK0886 represent new drug.
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sci-hub.se 参考文章(10)
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