摘要: Publisher Summary This chapter describes the molecular biology in eicosanoid field. Molecular made its main entrance to field, when two groups simultaneously reported cloning of cDNA for leukotriene A 4 hydrolase. Subsequently, field has expanded considerably include many interesting findings with lipoxygenases, prostaglandin-synthesizing enzymes, and prostanoid receptors. Availability genes these enzymes should allow targeting strategies discern potential functions. Clear information on regulation significance formation by 5-lipoxygenase, 5-lipoxygenase activating protein, hydrolase is still lacking. The recent discovery second form cyclooxygenase reopened a wide interest academic pharmaceutical communities prostaglandin research. differential forms development selective isoform inhibitors will be areas intensive Cloning different members receptor family facilitate our unravelling mechanisms involved action this class arachidonate metabolites known as eicosanoids.
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