Piperdine derivatives as NMDA receptor antagonists

摘要: The present invention relates to a compound of formula (I): wherein: V and U are hydrogen, halogen, C 1 -C 4 alkylamino, or together form group that contains one more heteroatoms, taken with more: (a) hydrogen atoms; (b) carbon (c) —CH═ groups; (d) —CH 2 — (e) additional heteroatoms the same different type; any combination thereof, 4-7 membered homocyclic heterocyclic ring, wherein ring may combine phenyl bicyclic contain oxo, thioxo, amino, mercapto, trifluoromethyl, alkyl, ═S —SH W: is —CO—, —(C alkyl)-; X: —CO—; Y: —O—, alkylene, alkynylene, cycloalkylene, aminocarbonyl, —NH—, —N(C alkyl)-, —C alkylene-N(C O—, —CH(OH)— —OCH —; Z: nitro, alkoxy, cyano, hydroxyl carboxyl; R : 3 bridge; n m: independently 0-3, m cannot each be 0; an optical antipode, racemate pharmaceutically-acceptable salt thereof. carboxylic acid amide derivatives (I) highly effective selective antagonists NMDA receptor.