Isolation and identification of angiotensin-converting enzyme inhibitory peptides from egg white protein hydrolysates.
作者： JingBo Liu , ZhiPeng Yu , WenZhu Zhao , SongYi Lin , ErLei Wang
DOI: 10.1016/J.FOODCHEM.2010.03.108
关键词:
摘要: Abstract The aim of this study was to identify potential angiotensin I-converting enzyme (ACE) inhibitory peptide from egg white protein. protein hydrolysed by Alcalase and the hydrolysates were isolated with Gel filtration get high activity fraction. fraction identified LC tandem mass spectrometric 4000 Q Trap MS. In current work, 19 peptides discovered in fractions, five which sourced ovotransferrin synthesised Fmoc solid phase method. ACE-inhibitory measured HPLC assay. 50% concentrations Arg–Val–Pro–Ser–Leu (RVPSL) 20 μM. Based on remarkable activity, it is suggested that RVPSL may have applications as a functional food, could be used nutraceutical compounds.
cabdirect.org
elsevier.com
sci-hub.se 参考文章(25)
M. Ramos, M. Miguel, R. López Fandiño, M. A. Aleixandre, Efecto de la clara de huevo tratada con pepsina sobre el desarrollo de hipertensión arterial en ratas hipertensas. Ciencia Y Tecnologia Alimentaria. ,vol. 4, pp. 368- 372 ,(2005)
Marta Miguel, Amaya Aleixandre, Antihypertensive Peptides Derived from Egg Proteins Journal of Nutrition. ,vol. 136, pp. 1457- 1460 ,(2006) , 10.1093/JN/136.6.1457
Marta Miguel, Rosina López-Fandiño, Mercedes Ramos, Amaya Aleixandre, Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats. Life Sciences. ,vol. 78, pp. 2960- 2966 ,(2006) , 10.1016/J.LFS.2005.11.025
Bo Li, Feng Chen, Xi Wang, Baoping Ji, Yonnie Wu, Isolation and identification of antioxidative peptides from porcine collagen hydrolysate by consecutive chromatography and electrospray ionization–mass spectrometry Food Chemistry. ,vol. 102, pp. 1135- 1143 ,(2007) , 10.1016/J.FOODCHEM.2006.07.002
Marta Miguel, Yolanda Alvarez, Rosina López-Fandiño, María J Alonso, Mercedes Salaices, None, Vasodilator effects of peptides derived from egg white proteins. Regulatory Peptides. ,vol. 140, pp. 131- 135 ,(2007) , 10.1016/J.REGPEP.2006.11.029
Anne Pihlanto, Sari Akkanen, Hannu J. Korhonen, ACE-inhibitory and antioxidant properties of potato (Solanum tuberosum). Food Chemistry. ,vol. 109, pp. 104- 112 ,(2008) , 10.1016/J.FOODCHEM.2007.12.023
Shin Joung Rho, Ji-Soo Lee, Yong Il Chung, Young-Wan Kim, Hyeon Gyu Lee, Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract Process Biochemistry. ,vol. 44, pp. 490- 493 ,(2009) , 10.1016/J.PROCBIO.2008.12.017
Jianping Wu, Rotimi E. Aluko, Alister D. Muir, Purification of angiotensin I-converting enzyme-inhibitory peptides from the enzymatic hydrolysate of defatted canola meal Food Chemistry. ,vol. 111, pp. 942- 950 ,(2008) , 10.1016/J.FOODCHEM.2008.05.009
Kaustav Majumder, Jianping Wu, Angiotensin i converting enzyme inhibitory peptides from simulated in vitro gastrointestinal digestion of cooked eggs Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 471- 477 ,(2009) , 10.1021/JF8028557
C PAPADIMITRIOU, A VAFOPOULOUMASTROJIANNAKI, S SILVA, A GOMES, F MALCATA, E ALICHANIDIS, Identification of peptides in traditional and probiotic sheep milk yoghurt with angiotensin I-converting enzyme (ACE)-inhibitory activity Food Chemistry. ,vol. 105, pp. 647- 656 ,(2007) , 10.1016/J.FOODCHEM.2007.04.028