Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats.
作者： Marta Miguel , Rosina López-Fandiño , Mercedes Ramos , Amaya Aleixandre
DOI: 10.1016/J.LFS.2005.11.025
关键词:
摘要: Abstract This paper evaluates the effect of long-term intake a hydrolysate egg white with pepsin (HEW), potent angiotensin converting enzyme inhibitory activity, on development hypertension spontaneously hypertensive rats (SHR). After being weaned, male 3-week-old SHR were randomly divided into five groups that given until 20th week life following drinking fluids: (1) tap water, (2) non-treated 1 g/kg/day, (3) captopril 100 mg/kg/day, (4) HEW 0.5 and (5) g/kg/day. From to 25th life, animals from all water. Systolic blood pressure (SBP) diastolic (DBP) measured weekly in rats, 6th by tail cuff method. Development was attenuated treated ( P
elsevier.com
sci-hub.se 参考文章(41)
A. DÁVALOS, M. MIGUEL, B. BARTOLOMÉ, R. LÓPEZ-FANDIÑO, Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis. Journal of Food Protection. ,vol. 67, pp. 1939- 1944 ,(2004) , 10.4315/0362-028X-67.9.1939
M. MIGUEL, I. RECIO, J. A. GÓMEZ-RUIZ, M. RAMOS, R. LÓPEZ-FANDIÑO, Angiotensin I-converting enzyme inhibitory activity of peptides derived from egg white proteins by enzymatic hydrolysis. Journal of Food Protection. ,vol. 67, pp. 1914- 1920 ,(2004) , 10.4315/0362-028X-67.9.1914
R D Buñag, Validation in awake rats of a tail-cuff method for measuring systolic pressure Journal of Applied Physiology. ,vol. 34, pp. 279- 282 ,(1973) , 10.1152/JAPPL.1973.34.2.279
Yuko YAMADA, Nobuyuki MATOBA, Hachiro USUI, Kunihiko ONISHI, Masaaki YOSHIKAWA, Design of a highly potent anti-hypertensive peptide based on ovokinin(2-7). Bioscience, Biotechnology, and Biochemistry. ,vol. 66, pp. 1213- 1217 ,(2002) , 10.1271/BBB.66.1213
Ronald A. Ferrone, Michael J. Antonaccio, Prevention of the development of spontaneous hypertension in rats by captopril (SQ 14,225) European Journal of Pharmacology. ,vol. 60, pp. 131- 137 ,(1979) , 10.1016/0014-2999(79)90211-5
JohnM. Cruickshank, JeffreyM. Thorp, F.James Zacharias, BENEFITS AND POTENTIAL HARM OF LOWERING HIGH BLOOD PRESSURE The Lancet. ,vol. 329, pp. 581- 584 ,(1987) , 10.1016/S0140-6736(87)90231-5
Beatriz Civantos, Amaya Aleixandre, Blood pressure and α-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca European Journal of Pharmacology. ,vol. 489, pp. 101- 110 ,(2004) , 10.1016/J.EJPHAR.2004.02.032
Beatriz Civantos, Visitación López-Miranda, Ana Ortega, M.Amaya Aleixandre de Artiñano, α-Adrenoceptor-mediated pressor responses in pithed rats fed diets with different calcium contents European Journal of Pharmacology. ,vol. 382, pp. 91- 101 ,(1999) , 10.1016/S0014-2999(99)00556-7
Visitación López-Miranda, Beatriz Civantos, Rafael Blasco, Rosario Hernández, María Amaya Aleixandre de Artiñano, Parathyroid Hormone and Calcitriol in Hypertension Caused by Dietary Calcium Deficiency in Rats Journal of Vascular Research. ,vol. 35, pp. 397- 404 ,(1998) , 10.1159/000025610
M. Miguel, B. Muguerza, E. Sánchez, M. A. Delgado, I. Recio, M. Ramos, M. A. Aleixandre, Changes in arterial blood pressure in hypertensive rats caused by long-term intake of milk fermented by Enterococcus faecalis CECT 5728. British Journal of Nutrition. ,vol. 94, pp. 36- 43 ,(2005) , 10.1079/BJN20051450