Angiotensin-converting enzyme activity in plasma and tissues of spontaneously hypertensive rats after the short- and long-term intake of hydrolysed egg white.

摘要: This paper evaluates the effects of short- (1 g/kg) and long-term (0.5 1 g/kg/day) oral intake egg white hydrolysed with pepsin (hEW) (EW) on local angiotensin-converting enzyme (ACE) activities in plasma other tissues spontaneously hypertensive rats (SHR), as compared to effect ACE inhibitor prototype captopril. The treated hEW were classed a different group than control EW by cluster analysis, taking into account their tissue systolic blood pressure (SBP). Principal component analysis (PCA) showed that SBP SHR was negatively related activity positively aorta kidney. significantly increased after treatment g/kg/day). kidney inhibited 4 h short-term administration hEW. caused aorta, lungs followed pattern similar, but less pronounced,