Analysis of the Dynamics of a Tumor–Immune System with Chemotherapy and Immunotherapy and Quadratic Optimal Control
作者： Swarnali Sharma , G. P. Samanta
DOI: 10.1007/S12591-015-0250-1
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摘要: In this paper, we consider a tumor growth model with the effect of tumor–immune interactions and chemotherapeutic as well immunotherapeutic drugs. our there are four compartments, namely cells, immune drug concentration concentration. The dynamical behaviour system by analyzing existence stability at various equilibria is discussed elaborately. We set up an optimal control problem relative to so minimize number cells drugs administration. Here use quadratic quantify goal administration chemotherapy controls reduce spread growth. important mathematical findings for also numerically verified using MATLAB. Finally epidemiological implications analytical addressed critically.
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