Application of optimal control theory to analysis of cancer chemotherapy regimens
作者： Alexey S. Matveev , Andrey V. Savkin
DOI: 10.1016/S0167-6911(02)00134-2
关键词:
摘要: Cancer chemotherapy with application of one drug is studied. The negative and inhibiting effect the tumor on normal cells taken into account. Under certain assumptions, we determine optimal regimen that minimizes burden at end a fixed period therapy while maintaining cell population above prescribed level.
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