The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
作者： Chi-chung Hui , Paul T. Sharpe , Rong Mo , Zoë Hardcastle
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摘要: The expression of genes involved in the Sonic Hedgehog signalling pathway, including Shh, Ptc, Smo, Gli1, Gli2 and Gli3, were found to be expressed temporal spatial patterns during early murine tooth development, suggestive a role germ initiation subsequent epithelial-mesenchymal interactions. Of these Gli3 epithelium mesenchyme whereas Shh was only detected epithelium. This suggests that is both lateral (epithelial-mesenchymal) planar (epithelial-epithelial) development. Ectopic application protein mandibular induced Ptc Gli1. Addition exogenous directly into germs adjacent germs, resulted abnormal epithelial invagination, indicative for cell proliferation. In order assess possible this development mutant embryos investigated. mutants have maxillary incisors, probably resulting from mild holoprosencephaly, had no major abnormalities. Gli2/Gli3 double homozygous did not develop any normal teeth survive beyond embryonic day 14.5; however, Gli2(−/−); Gli3(+/−) until birth small molars incisors incisor arrested as rudimentary thickening. These results show an essential involves functional redundancy downstream Gli genes.
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