The Metastatic Process: An Overview

摘要: About one third of patients who will receive a cancer diagnostic die this disease. In most cases, death results from the formation secondary neoplasms called metastases. The metastatic process is characterized by detachment cells primary sites followed their dissemination throughout bloodstream and/or lymph stream to distal where they proliferate give rise tumours. Intriguingly, rather inefficient and in spite its clinical significance, it remains poorly understood. Nevertheless, significant progress has been achieved during past years increasing knowledge encouraging raises high therapeutic expectations. Several events that lead metastasis are under genetic epigenetic controls. particular, initiation tightly associated with specific mutations affect proto-oncogenes tumour suppressor genes. These unrestrained growth neoplasm propensity detach through subsequent steps dissemination. Epigenetic alterations mainly deregulation DNA methylation microRNA (miRNA)-dependent functions, as well disruption histone modifiers chromatin-remodelling factors. addition these molecular alterations, several studies highlight development rely on continuous crosstalk between microenvironments. This chapter provide an overview applies colorectal cancer.