Myeloperoxidase is a primary response gene in HL60 cells, directly regulated during hematopoietic differentiation.
作者： R.W. Meier , T. Chen , R.R. Friis , A. Tobler
DOI: 10.1016/0006-291X(91)90434-9
关键词:
摘要: Abstract The expression of myeloperoxidase was studied in three human myeloid leukemic cell lines. myeloperxidase transcript strongly expressed promyelocytic HL 60 cells, whereas much lower levels were detected immature monocytic U 937 cells. Phorbol-12-myristate-13-acetate induction resulted inhibition within 24hrs. This regulatory event could not be blocked by cycloheximide. Furthermore, cycloheximide did superinduce mRNA KG 1, and arguing against the existence a negative gene regulator for myeloperoxidase. Therefore, can classified as primary response gene.
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