The emerging impact of tRNA modifications in the brain and nervous system.
作者： Jillian Ramos , Dragony Fu
DOI: 10.1016/J.BBAGRM.2018.11.007
关键词:
摘要: A remarkable number of neurodevelopmental disorders have been linked to defects in tRNA modifications. These discoveries place modifications the spotlight as critical modulators gene expression pathways that are required for proper organismal growth and development. Here, we discuss emerging molecular cellular functions diverse cognitive neurological disorders. In particular, describe how structure location a modification influences folding, stability, function. We then highlight can impact multiple aspects protein translation instrumental maintaining proteostasis. Importantly, perturbations lead spectrum deleterious biological outcomes disturb neurodevelopment Finally, summarize themes shared by different offer insight into future questions remain decipher role This article is part Special Issue entitled: mRNA control edited Dr. Soller Matthias Fray Rupert.
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