Differential effects of epinephrine on glucose production and disposal in man.

摘要: Normal subjects were infused 1) with epinephrine (50 ng/(kg.min)) for 180 min followed by plus glucagon (3 60 after which the infusion rate was increased (125 or 2) somatostatin (500 microgram/h) min. Epinephrine glucose production and plasma transiently but caused persistent suppression of clearance sustained hyperglycemia (despite insulin gluconeogenic substrates); again on addition increasing rate. During somatostatin, still transiently, further more marked hyperglycemia. In conclusion, in man hyperepinephrinemia within physiological range only a transient increase production; this hepatic response a) not due to glycogen substrate depletion, b) occurred without changes insulin, c) specific permitted subsequent responses epinephrine; 3) can serve as regulator homeostasis both decreasing clearance.